Agmatine significantly lengthened exercise time before athletes were immobilized by exhaustion. Researchers note effects seem strongest when agmatine is supplemented within 30 minutes prior to exercise. Agmatine is the only molecule known to scientists with the capability to induce antizyme. This enhances cell growth and homeostasis and is proven to increase cell count per unit of surface area by 10-17%. Argmatine stimulates pituitary hormone secretion, including growth hormone. Raising growth hormone maximizes the speed and size of muscle growth. It’s also proven to improve muscle strength by 24-62%
1. Sener A, Lebrun P, Blachier F, Malaisse W. Biochem Pharmacol. 1989, 38, 327–30.
2. Joseph Satriano, Carolyn J Kelly, Roland C Blantz. Kidney International. 1999,56, 1252-1253.
3.Kazuhiro Tanahashi and Antonios G. Mikos. Journal of Biomedical Materials Research Part A.2003,67,448-457.
4. Satya P. Kaira, Edward Pearson, Abhiram Sahu, Pushpa S. Kalra. Neuroscience Letters. 1995,194, 165-168.
5.Dennis R. Taaffe, Leslie Pruitt, Jennifer Reim, Raymond L. Hintz, Gail Butterfield, Andrew R. Hoffman, Robert Marcus. Journal
The influence of agmatine on nitric oxide production, norepinephrine release and related receptor systems indicate its potential cardioprotective benefits associated with these mechanisms as well. Not only can agmatine directly and immediately support healthy cardiovascular function, but it may protect related systems to promote future health and stability should challenges arise. Soo Kyung Ahn , Samin Hong, Yu Mi Park. Life Sciences 2012, 91, 1345–1350
Agmatine attenuates neuropathic pain and inhibits self-administration. It can modulate both acute and chronic pain caused by sciatic nerve damage. It can boost your workouts by making you more inclined to work.
1.Carrie L. Wade b, Daniel J. Schuster c, Kristine M. Domingo, et al. European Journal of Pharmacology. 2008, 587:135–140.
2.Nandkishor Ramdas Kotagale, Saurabh Haridas Shirbhate, Pradeep Shukla, et al. European JournalofPharmacology 2013, 714, 424–431.
3.Rui-Bin Su , Wei-Ping Wang, Xin-Qiang Lu, et al. Pharmacology, Biochemistry and Behavior. 2009, 92, 676–682.
Agmatine reduces stress placed on the brain, especially in the prefrontal cortex and hippocampus. It also enhances motoneuron and nerve recovery and is used to treat facial nerve damage because it accelerates healing and results in more complete nerve rehabilitation. It appears to modulate a variety of neurotransmitter receptors and signaling channels. Furthermore, there's evidence that agmatine acts directly as a co-neurotransmitter and, in fact, it does fulfill the clinical criteria for a neurotransmitter.
1. Donald J. Reis and Soundararajan Regunathan. Trends in Pharmacological Sciences. 2000, 21, 187-193.
2. Meng-Yang Zhu, Wei-Ping Wang,Gregory Ordway, et al. Eur J Neurosci. 2008, 27, 1320-1332.
3. Gad M Gilad and Varda H Gilad. Neuroscience Letters, 2000, 296, 97-100
4. Leonard Berenholz, Shmuel Segal, Varda H. Gilad, et al. Journal of the Peripheral Nervous System. 2005,10, 319-328.